Dr. Brian Greuel Research

Dr. Brian Greuel's current research centers around the regulation of a gene called the myelin proteolipid protein gene that is essential for the normal function of the myelin sheath in the central nervous system. Defects in the function or regulation of this gene lead to specific neurodegenerative disorders in humans and other mammals. This research is currently funded by a grant from the Arkansas Idea Network for Biomedical Research.

Students participate in the design of experiments and are actively involved in all phases of carrying out the experiments, analyzing and interpreting the results and presenting the findings at regional and national conferences. Students learn and perform basic techniques in recombinant DNA (cloning) technology, mammalian cell culture, nucleic acid purification, mutagenesis, gel electrophoresis, gene transfer, and other techniques in cellular/molecular biology.

This research has led to important findings that may someday be used to upregulate or downregulate expression of the gene in order to restore function to the central nervous system in individuals afflicted with various neurodegenerative disorders.